Source:http://linkedlifedata.com/resource/pubmed/id/17370341
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2007-11-20
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| pubmed:abstractText |
Oscillatory brain activity in the alpha band (8-13 Hz) is modulated by cognitive events. Such modulation is reflected in a decrease of alpha (event-related desynchronization; ERD) with high cognitive load, or an increase (event-related synchronization) with low cognitive demand or with active inhibition of distractors. We used magnetoencephalography to investigate the pattern of prefrontal and parieto-occipital alpha modulation related to two variants of visual working memory task (delayed matching-to-sample) with and without a distractor. We tested nonmedicated, nondepressed patients suffering obsessive-compulsive disorder (OCD), and pair-matched healthy controls. The level of event-related alpha as a function of time was estimated using the temporal-spectral evolution technique. The results in OCD patients indicated: (1) a lower level of prestimulus (reference) alpha when compared to controls, (2) a task-phase specific reduction in event-related alpha ERD in particular for delayed matching-to-sample task with distractor, (3) no significant correlations between the pattern of modulation in prefrontal and parietal-occipital alpha oscillatory activity. Despite showing an abnormally low alpha modulation, the OCD patients' performance accuracy was normal. The results suggest a relationship of alpha oscillations and the underlying thalamocortical network to etiology of OCD and an involvement of a compensatory mechanism related to effortful inhibition of extrinsic and intrinsic interference.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1065-9471
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| pubmed:author | |
| pubmed:copyrightInfo |
(copyright) 2007 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
28
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1401-14
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| pubmed:meshHeading |
pubmed-meshheading:17370341-Adolescent,
pubmed-meshheading:17370341-Adult,
pubmed-meshheading:17370341-Alpha Rhythm,
pubmed-meshheading:17370341-Cortical Synchronization,
pubmed-meshheading:17370341-Evoked Potentials,
pubmed-meshheading:17370341-Female,
pubmed-meshheading:17370341-Humans,
pubmed-meshheading:17370341-Image Processing, Computer-Assisted,
pubmed-meshheading:17370341-Magnetoencephalography,
pubmed-meshheading:17370341-Male,
pubmed-meshheading:17370341-Memory, Short-Term,
pubmed-meshheading:17370341-Obsessive-Compulsive Disorder,
pubmed-meshheading:17370341-Occipital Lobe,
pubmed-meshheading:17370341-Parietal Lobe,
pubmed-meshheading:17370341-Patch-Clamp Techniques,
pubmed-meshheading:17370341-Prefrontal Cortex,
pubmed-meshheading:17370341-Psychiatric Status Rating Scales,
pubmed-meshheading:17370341-Psychomotor Performance,
pubmed-meshheading:17370341-Reaction Time,
pubmed-meshheading:17370341-Visual Perception
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| pubmed:year |
2007
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| pubmed:articleTitle |
Dissociation between MEG alpha modulation and performance accuracy on visual working memory task in obsessive compulsive disorder.
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| pubmed:affiliation |
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ktc@nmr.mgh.harvard.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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