Linked Life Data

17369700

Source:http://linkedlifedata.com/resource/pubmed/id/17369700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-3-19
pubmed:abstractText
Protein Fv was isolated and purified by Jean Pierre Bouvet and collaborators in 1990 from stool extracts of patients affected by viral hepatitis B or C. This protein was also identified and purified in biological samples in experimental viral hepatitis. Under normal conditions, protein Fv is synthesized in low concentrations by the human liver, and is increased in biological fluids of patients with viral hepatitis. This protein binds with high affinity to the variable domain of the heavy chains of all human immunoglobulins. Thus, it is an endogenous immunoglobulin superantigen because it binds to human immunoglobulin of the VH3 family. This protein also acts as a superallergen because it activates human basophils and mast cells through the high-affinity interaction with IgE VH3+. The mechanism of activation of immune cells by protein Fv represents a new pathogenetic cascade consisting of viral infection, endogenous immunoglobulin superantigen/superallergen production and tissue injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1660-2242
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-76
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Protein Fv: an endogenous immunoglobulin superantigen and superallergen.
pubmed:affiliation
Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research, University of Naples Federico II, School of Medicine, Naples, Italy.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't