| pubmed-article:17369348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C0317951 | lld:lifeskim |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C0044010 | lld:lifeskim |
| pubmed-article:17369348 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:17369348 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17369348 | pubmed:dateCreated | 2007-5-14 | lld:pubmed |
| pubmed-article:17369348 | pubmed:abstractText | The production of 1,4-dihydroxy-2-naphthoic acid (DHNA) was investigated using a fed-batch culture of Propionibacterium freudenreichii ET-3. DHNA is a precursor of menaquinone (MK) and is transformed to MK by combination with an isoprenoid unit. We found that ET-3 stopped MK production and increased DHNA production in an anaerobic fed-batch culture by maintaining the lactose concentration at approximately zero. The maximum DHNA concentration observed in the anaerobic fed-batch culture was markedly higher than the maximum DHNA concentration observed in an anaerobic batch culture. Moreover, MK or DHNA production was affected by the lactose feeding rate; this suggests that lactose metabolism participates in the syntheses of these products. On the other hand, accumulation of propionate was found to inhibit DHNA production in the fed-batch culture. Based on the fact that ET-3 increases DHNA production in an aerobic culture by consuming propionate, we carried out a cultivation experiment in which an anaerobic fed-batch culture was switched to an anaerobic batch culture and found that the DHNA production was increased to a greater extent than the DHNA production in an anaerobic fed-batch culture. These results suggest that DHNA production by ET-3 is markedly influenced by carbon source limitation and the oxygen supply. | lld:pubmed |
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| pubmed-article:17369348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17369348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17369348 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17369348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17369348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17369348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17369348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17369348 | pubmed:month | May | lld:pubmed |
| pubmed-article:17369348 | pubmed:issn | 0099-2240 | lld:pubmed |
| pubmed-article:17369348 | pubmed:author | pubmed-author:ShioyaSuteaki... | lld:pubmed |
| pubmed-article:17369348 | pubmed:author | pubmed-author:NinomiyaKazua... | lld:pubmed |
| pubmed-article:17369348 | pubmed:author | pubmed-author:KatakuraYoshi... | lld:pubmed |
| pubmed-article:17369348 | pubmed:author | pubmed-author:FuruichiKeisu... | lld:pubmed |
| pubmed-article:17369348 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17369348 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:17369348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17369348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17369348 | pubmed:pagination | 3137-43 | lld:pubmed |
| pubmed-article:17369348 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:meshHeading | pubmed-meshheading:17369348... | lld:pubmed |
| pubmed-article:17369348 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17369348 | pubmed:articleTitle | Enhancement of 1,4-dihydroxy-2-naphthoic acid production by Propionibacterium freudenreichii ET-3 fed-batch culture. | lld:pubmed |
| pubmed-article:17369348 | pubmed:affiliation | Food Technology Research Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. keisuke_furuichi@meiji-milk.com | lld:pubmed |
| pubmed-article:17369348 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17369348 | lld:pubmed |
