|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2007-5-14
|
|
pubmed:abstractText |
The production of 1,4-dihydroxy-2-naphthoic acid (DHNA) was investigated using a fed-batch culture of Propionibacterium freudenreichii ET-3. DHNA is a precursor of menaquinone (MK) and is transformed to MK by combination with an isoprenoid unit. We found that ET-3 stopped MK production and increased DHNA production in an anaerobic fed-batch culture by maintaining the lactose concentration at approximately zero. The maximum DHNA concentration observed in the anaerobic fed-batch culture was markedly higher than the maximum DHNA concentration observed in an anaerobic batch culture. Moreover, MK or DHNA production was affected by the lactose feeding rate; this suggests that lactose metabolism participates in the syntheses of these products. On the other hand, accumulation of propionate was found to inhibit DHNA production in the fed-batch culture. Based on the fact that ET-3 increases DHNA production in an aerobic culture by consuming propionate, we carried out a cultivation experiment in which an anaerobic fed-batch culture was switched to an anaerobic batch culture and found that the DHNA production was increased to a greater extent than the DHNA production in an anaerobic fed-batch culture. These results suggest that DHNA production by ET-3 is markedly influenced by carbon source limitation and the oxygen supply.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-10194395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-10650075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-10811225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-11790756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-11833775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-12005071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-15771560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-16935247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-17046533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-4436264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-4647470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-6127606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-6380538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-7273844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-8182163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-8240251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-8405922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17369348-8645235
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0099-2240
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3137-43
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Enhancement of 1,4-dihydroxy-2-naphthoic acid production by Propionibacterium freudenreichii ET-3 fed-batch culture.
|
|
pubmed:affiliation |
Food Technology Research Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan. keisuke_furuichi@meiji-milk.com
|
|
pubmed:publicationType |
Journal Article
|
