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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-4-20
pubmed:abstractText
We analyzed the safety and efficacy of gemtuzumab ozogamicin (GO) combined with cytarabine and mitoxantrone in the treatment of 21 patients with acute myeloid leukemia (11 refractory and 10 in second relapse). Patients' median age was 52 years (range 36-68); all patients had previously been treated with anthracycline-containing regimens (daunorubicin and idarubicin). GO at a dosage of 3 mg/m2 was administered as a 2-h intravenous infusion on days 1 and 14, cytarabine at 100 mg/m2 on days 1-7, and mitoxantrone at 12 mg/m2 on days 1-3. Infusion-related events were observed in 15 of 21 (71.4%) patients. The incidence of grade 1 or 2 elevations of bilirubin and hepatic transaminases was 4 of 21 (19%) and 3 of 21 (14.2%). In response to chemotherapy, 2 of 21 (9.5%) achieved complete remission and 2 of 21 (9.5%) achieved complete remission with incomplete platelet recovery, with an overall remission rate of 4 of 21(19%); median survival of these 4 patients was 7 months. Four of 21 patients (19%) died during aplasia after chemotherapy; no veno-occlusive disease occurred. No treatment-related cardiotoxicity or cerebellar toxicity was observed. In our experience, the addition of GO to mitoxantrone and cytarabine is feasible in refractory or second relapse acute myeloid leukemia patients but yields a low response rate when used as a third-line treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0939-5555
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17364181-Acute Disease, pubmed-meshheading:17364181-Adult, pubmed-meshheading:17364181-Aged, pubmed-meshheading:17364181-Aminoglycosides, pubmed-meshheading:17364181-Antibodies, Monoclonal, pubmed-meshheading:17364181-Antibodies, Monoclonal, Humanized, pubmed-meshheading:17364181-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:17364181-Cytarabine, pubmed-meshheading:17364181-Female, pubmed-meshheading:17364181-Humans, pubmed-meshheading:17364181-Leukemia, Myeloid, pubmed-meshheading:17364181-Male, pubmed-meshheading:17364181-Middle Aged, pubmed-meshheading:17364181-Mitoxantrone, pubmed-meshheading:17364181-Palliative Care, pubmed-meshheading:17364181-Remission Induction, pubmed-meshheading:17364181-Salvage Therapy, pubmed-meshheading:17364181-Survival Analysis
pubmed:year
2007
pubmed:articleTitle
Gemtuzumab ozogamicin with cytarabine and mitoxantrone as a third-line treatment in a poor prognosis group of adult acute myeloid leukemia patients: a single-center experience.
pubmed:affiliation
Hematology Section, DAP, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy. g.specchia@ematba.uniba.it
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't