Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-3-10
pubmed:abstractText
Glucose is the main fuel for energy metabolism in the normal human brain. It is generally assumed that glucose transport into the brain is not rate-limiting for metabolism. Since brain glucose concentrations cannot be determined directly by radiotracer techniques, we used 13C NMR spectroscopy after infusing enriched D-[1-13C]glucose to measure brain glucose concentrations at euglycemia and at hyperglycemia (range, 4.5-12.1 mM) in six healthy children (13-16 years old). Brain glucose concentrations averaged 1.0 +/- 0.1 mumol/ml at euglycemia (4.7 +/- 0.3 mM plasma) and 1.8-2.7 mumol/ml at hyperglycemia (7.3-12.1 mM plasma). Michaelis-Menten parameters of transport were calculated to be Kt = 6.2 +/- 1.7 mM and Tmax = 1.2 +/- 0.1 mumol/g.min from the relationship between plasma and brain glucose concentrations. The brain glucose concentrations and transport constants are consistent with transport not being rate-limiting for resting brain metabolism at plasma levels greater than 3 mM.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-1714544, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-1997495, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2013760, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2092742, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2185663, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2211679, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2302536, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2403659, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2540398, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2560801, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2701278, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2747510, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2871798, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-2881185, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3079285, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3081208, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3207358, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3259623, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3260686, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3491192, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3492786, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3532161, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-375257, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-382871, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-3839598, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-4144557, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-4754872, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-4761701, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-5099620, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-5124307, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-6361813, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-6874739, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-7035472, http://linkedlifedata.com/resource/pubmed/commentcorrection/1736294-7104768
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1109-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.
pubmed:affiliation
Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06510.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't