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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-4
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pubmed:abstractText |
Receptor activator of nuclear factor-kappaB ligand (RANKL) promotes osteoclast differentiation from monocyte precursors by inducing a cohort of genes, including tartrate-resistant acid phosphatase (TRAP) and matrix metalloproteinase-9 (MMP-9). A family of synthetic triterpenoids with antiinflammatory and pro-apoptotic properties was described to modulate differentiation in monocytic cell lineages. We therefore investigated the ability of the potent and bioavailable synthetic triterpenoid TP-222 to inhibit RANKL-induced osteoclast formation and MMP-9 expression from monocytic precursor cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1058-68
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17361985-Animals,
pubmed-meshheading:17361985-Bone Marrow Cells,
pubmed-meshheading:17361985-Bone Resorption,
pubmed-meshheading:17361985-Cell Count,
pubmed-meshheading:17361985-Cell Line,
pubmed-meshheading:17361985-Drug Combinations,
pubmed-meshheading:17361985-Enzyme Inhibitors,
pubmed-meshheading:17361985-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17361985-Injections, Intraperitoneal,
pubmed-meshheading:17361985-Macrophages,
pubmed-meshheading:17361985-Matrix Metalloproteinase 9,
pubmed-meshheading:17361985-Mice,
pubmed-meshheading:17361985-Mice, Inbred C57BL,
pubmed-meshheading:17361985-Monocytes,
pubmed-meshheading:17361985-Nitric Oxide,
pubmed-meshheading:17361985-Osteoclasts,
pubmed-meshheading:17361985-Osteogenesis,
pubmed-meshheading:17361985-RANK Ligand,
pubmed-meshheading:17361985-RNA, Messenger,
pubmed-meshheading:17361985-Triterpenes
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pubmed:year |
2007
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pubmed:articleTitle |
The synthetic triterpenoid TP-222 inhibits RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expression.
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pubmed:affiliation |
Research Service, Veterans Affairs Medical Center, White River Junction, Vermont, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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