Linked Life Data

17360841

Source:http://linkedlifedata.com/resource/pubmed/id/17360841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-5-7
pubmed:abstractText
This study aimed to reconstruct the evolutionary history of Beijing strains of Mycobacterium tuberculosis and to test the hypothesis that evolution has influenced the ability of the Beijing strains within the different Beijing sublineages to spread and cause disease. A PCR-based method was used to analyze the genome structure of 40 different loci in 325 Beijing isolates collected from new and retreatment tuberculosis patients from an urban setting and 270 Beijing isolates collected from high-risk tuberculosis patients from a rural setting in the Western Cape, South Africa. The resulting data were subjected to phylogenetic analysis using the neighbor joining algorithm. Phylogenetic reconstructions were highly congruent with the "gold standard" phylogenetic tree based on synonymous single-nucleotide polymorphisms, thereby allowing a prediction of the order in which the evolutionary events had occurred. A total of seven independently evolving Beijing sublineages were identified. Analysis of epidemiological data in relation to the Beijing sublineage suggested an association between recent evolutionary change and frequency of occurrence in an urban population (P<0.001) as well as in the rural population (P<0.001). This concept was further supported by an association between more recently evolved Beijing strains and an increased ability to transmit and to cause disease (odds ratio, 5.82; 95% confidence interval, 3.13 to 10.82 [P<0.001]). An association between Beijing sublineage and demographic and clinical parameters and drug resistance could not be demonstrated. From these data, we suggest that the pathogenic characteristics of Beijing strains are not conserved but rather that strains within individual lineages have evolved unique pathogenic characteristics.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-10921952, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-11747703, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-11755085, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-12037045, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-12141971, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-12558181, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-12890325, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-15024109, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-15941801, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16000433, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16169923, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16207386, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16385065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16820066, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16890008, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-16957037, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-8381814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-8586708, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-8685780, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-9157152, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360841-9634230
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1483-90
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease.
pubmed:affiliation
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't