Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-3-15
pubmed:abstractText
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-10401912, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-10553730, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-10677034, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-10766253, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-11054589, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-11210998, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-11346191, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-12042200, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-12084413, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-12440973, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-12562575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-12629531, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15028725, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-1504403, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15058305, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15600382, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15795750, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15816794, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-15998156, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16054041, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16135655, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16172203, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16493121, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16525061, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16644800, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16690704, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16704352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16872808, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-16879084, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-2125973, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-2564258, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-2908065, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-2908235, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-3046553, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-3237844, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-648590, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-7700379, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-9283714, http://linkedlifedata.com/resource/pubmed/commentcorrection/17360666-9619146
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3456-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.
pubmed:affiliation
The Solomon H. Snyder Department of Neuroscience, Departments of Pharmacology and Molecular Sciences and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural