| pubmed-article:17360386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C1366903 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C1550315 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C1539895 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17360386 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:17360386 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17360386 | pubmed:dateCreated | 2007-3-21 | lld:pubmed |
| pubmed-article:17360386 | pubmed:abstractText | The small ubiquitin-like modifier (SUMO)-1 is an important posttranslational regulator of different signaling pathways and involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies (NBs). Overexpression of SUMO-1 has been associated with alterations in apoptosis, but the underlying mechanisms and their relevance for human diseases are not clear. Here, we show that the increased expression of SUMO-1 in rheumatoid arthritis (RA) synovial fibroblasts (SFs) contributes to the resistance of these cells against Fas-induced apoptosis through increased SUMOylation of nuclear PML protein and increased recruitment of the transcriptional repressor DAXX to PML NBs. We also show that the nuclear SUMO-protease SENP1, which is found at lower levels in RA SFs, can revert the apoptosis-inhibiting effects of SUMO-1 by releasing DAXX from PML NBs. Our findings indicate that in RA SFs overexpression of SENP1 can alter the SUMO-1-mediated recruitment of DAXX to PML NBs, thus influencing the proapoptotic effects of DAXX. Accumulation of DAXX in PML NBs by SUMO-1 may, therefore, contribute to the pathogenesis of inflammatory disorders. | lld:pubmed |
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| pubmed-article:17360386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17360386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17360386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17360386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17360386 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17360386 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:HayRonald TRT | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:GaySteffenS | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:PapThomasT | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:GayRenate ERE | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:PetersMarvin... | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:DankbarBernoB | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:WilleAlineA | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:BaierAnjaA | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:InkBarbaraB | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:DryndaAndreas... | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:CinskiAntjeA | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:MeineckeIngma... | lld:pubmed |
| pubmed-article:17360386 | pubmed:author | pubmed-author:MendozaHeidiH | lld:pubmed |
| pubmed-article:17360386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17360386 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:17360386 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17360386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17360386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17360386 | pubmed:pagination | 5073-8 | lld:pubmed |
| pubmed-article:17360386 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17360386 | pubmed:year | 2007 | lld:pubmed |
