Linked Life Data

17359936

Source:http://linkedlifedata.com/resource/pubmed/id/17359936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-3-27
pubmed:abstractText
To elucidate the role of the community effect in cardiomyocytes, we developed an on-chip single-cell-based culture system with which the dynamics of the change of beat rate and beat rate fluctuation of cultured cardiomyocytes can be measured at the single-cell level before and after the formation of a cell network. We examined the dependence of the community effect on cell network pattern by culturing cardiomyocytes in differently shaped microchambers and investigated the relation between the network pattern and the stability of the beat rate. We found that beat rate fluctuation tends to decrease as cell-community size increases, irrespective of cell network pattern. This indicates that on-chip single-cell-based cardiomyocyte communities might be able to model a heart tissue accurately enough to be used in practical applications such as drug screening.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
356
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
494-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Dependence of the community effect of cultured cardiomyocytes on the cell network pattern.
pubmed:affiliation
Department of Biomedical Information, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't