Linked Life Data

17359919

Source:http://linkedlifedata.com/resource/pubmed/id/17359919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-3-15
pubmed:abstractText
The role of the axonal membrane compartment in synaptic integration is usually neglected. We show here that in interneurons of the cerebellar molecular layer, where dendrites are so short that the somatodendritic domain can be considered isopotential, the axonal membrane contributes a significant part of the cell input capacitance. We examine the impact of axonal membrane on synaptic integration by cutting the axon with two-photon illumination. We find that the axonal compartment acts as a sink for signals generated at fast conductance synapses, thus increasing the initial decay rate of corresponding synaptic potentials over the value predicted from the resistance-capacitance (RC) product of the cell membrane; signals generated at slower synapses are much less affected. This mechanism sharpens the spike firing precision of fast glutamatergic inputs without resorting to multisynaptic pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
843-55
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Axonal speeding: shaping synaptic potentials in small neurons by the axonal membrane compartment.
pubmed:affiliation
Laboratoire de Physiologie Cérébrale, UFR Biomédicale, Université Paris 5, 45 Rue des Saints Pères, 75006 Paris, France.
pubmed:publicationType
Journal Article, In Vitro