17356514

Source:http://linkedlifedata.com/resource/pubmed/id/17356514

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017337, umls-concept:C0026809, umls-concept:C0035322, umls-concept:C0035331, umls-concept:C0185023, umls-concept:C0237497, umls-concept:C0243067, umls-concept:C0547070, umls-concept:C0596290, umls-concept:C0596988, umls-concept:C1314972, umls-concept:C1332737, umls-concept:C1947904, umls-concept:C1999228, umls-concept:C2825781
pubmed:dateCreated	2007-3-14
pubmed:abstractText	Little is known about the mechanisms that regulate cell cycle withdrawal of the retinal pigment epithelium (RPE) during development, or about the mechanisms maintaining epithelial cell quiescence in adult retinas. The present study examines the potential role of the negative cell cycle regulator p27(Kip1) in controlling RPE proliferation, using mice with targeted ablation of the p27(Kip1) gene.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/EY13760, http://linkedlifedata.com/resource/pubmed/grant/EY14559, http://linkedlifedata.com/resource/pubmed/grant/R01 EY013760-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 EY013760-02, http://linkedlifedata.com/resource/pubmed/grant/R01 EY013760-03, http://linkedlifedata.com/resource/pubmed/grant/R01 EY013760-04
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9605351
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...
pubmed:status	MEDLINE
pubmed:issn	1090-0535
pubmed:author	pubmed-author:AdamsLorrie B SLB, pubmed-author:DefoeDennis MDM, pubmed-author:LevineEdward MEM, pubmed-author:SunJingruJ, pubmed-author:WisecarverSarah NSN
pubmed:issnType	Electronic
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	273-86
pubmed:dateRevised	2010-9-14
pubmed:meshHeading	pubmed-meshheading:17356514-Animals, pubmed-meshheading:17356514-Cell Proliferation, pubmed-meshheading:17356514-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:17356514-Gene Deletion, pubmed-meshheading:17356514-Mice, pubmed-meshheading:17356514-Mice, Inbred C57BL, pubmed-meshheading:17356514-Mice, Knockout, pubmed-meshheading:17356514-Microscopy, Electron, pubmed-meshheading:17356514-Microvilli, pubmed-meshheading:17356514-Pigment Epithelium of Eye, pubmed-meshheading:17356514-Retinal Detachment, pubmed-meshheading:17356514-Rod Cell Outer Segment
pubmed:year	2007
pubmed:articleTitle	Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation.
pubmed:affiliation	Department of Anatomy and Cell Biology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614-0582, USA. defoe@etsu.edu <defoe@etsu.edu>
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural