|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0020517,
umls-concept:C0023516,
umls-concept:C0023981,
umls-concept:C0032659,
umls-concept:C0086418,
umls-concept:C0205430,
umls-concept:C0220908,
umls-concept:C0663655,
umls-concept:C1556084
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-4-26
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|
pubmed:abstractText |
The association of human leukocyte antigen-B*5701 with abacavir hypersensitivity varies depending on ethnic origin. We confirmed the high specificity of B*5701 in the ethnically mixed French population and used a rapid and inexpensive polymerase chain reaction strategy to evaluate the predictiveness of B*5701 screening. The incidence of hypersensitivity decreased from 12% before screening to 0% after screening, and the rate of unwarranted interruptions of abacavir therapy decreased from 10.2% to 0.73%. We therefore recommend the implementation of this cost-effective screen before treatment with abacavir.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
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pubmed:issn |
1525-4135
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
1
|
|
pubmed:volume |
45
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1-3
|
|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17356469-African Continental Ancestry Group,
pubmed-meshheading:17356469-Anti-HIV Agents,
pubmed-meshheading:17356469-Dideoxynucleosides,
pubmed-meshheading:17356469-European Continental Ancestry Group,
pubmed-meshheading:17356469-Female,
pubmed-meshheading:17356469-France,
pubmed-meshheading:17356469-Genetic Testing,
pubmed-meshheading:17356469-HIV,
pubmed-meshheading:17356469-HIV Infections,
pubmed-meshheading:17356469-HLA-B Antigens,
pubmed-meshheading:17356469-Humans,
pubmed-meshheading:17356469-Hypersensitivity,
pubmed-meshheading:17356469-Incidence,
pubmed-meshheading:17356469-Male,
pubmed-meshheading:17356469-Middle Aged,
pubmed-meshheading:17356469-Polymerase Chain Reaction,
pubmed-meshheading:17356469-Predictive Value of Tests,
pubmed-meshheading:17356469-Prospective Studies,
pubmed-meshheading:17356469-Retrospective Studies,
pubmed-meshheading:17356469-Sensitivity and Specificity,
pubmed-meshheading:17356469-Suburban Population,
pubmed-meshheading:17356469-Urban Population
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Prospective screening for human leukocyte antigen-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population.
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|
pubmed:affiliation |
Réseau Ville-Hopital Val de Seine, Hopital Foch, Suresnes, France.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
