Linked Life Data

17353958

Source:http://linkedlifedata.com/resource/pubmed/id/17353958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-3-13
pubmed:abstractText
Two highly charged zinc complexes, [Zn(L1)3](ClO4)8.4H2O (1) and [Zn(L2)2Br](ClO4)5.H2O (2) (L1 = 5,5'-di(1-(triethylammonio)methyl)-2,2'-dipyridyl and L2= 5,5'-di(1-(tributylammonio)methyl)-2,2'-dipyridyl) were synthesized and structurally characterized by crystallography. The zinc atom in 1 shows a distorted octahedral sphere. Variable-pH NMR studies on 1 demonstrated that the saturated six-coordinated [Zn(L1)3]8+ species can partially change into five-coordinated [Zn(L1)2(H2O)]6+ species in aqueous solution. The zinc atom in 2 shows a distorted trigonal-bipyramidal sphere. The average distance of the coordinated Br atom to the cationic N atom in 2 is ca 5.9 A, which is comparable to that of adjacent phosphodiesters in the DNA (ca. 6 A). Both complexes exhibited high nuclease activities towards cleavage of supercoiled plasmid DNA with the activity being the maximum under physiological pH. The effective DNA cleavage may be attributed to the strong electrostatic interaction of the metal moiety and two positive pendants with phosphodiester groups of nucleic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1477-9226
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1250-4
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cleavage of double-strand DNA by zinc complexes of dicationic 2,2'-dipyridyl derivatives.
pubmed:affiliation
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't