Linked Life Data

17352650

Source:http://linkedlifedata.com/resource/pubmed/id/17352650

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-5-16
pubmed:abstractText
Human BMSSCs lose telomerase activity in vitro, which leads to chromosomal instability and cellular senescence. We observed an inverse expression pattern between the osteogenic master regulatory gene, CBFA1, and the stem cell-associated gene, hTERT. We showed that Cbfa1 acts as a partial repressor of TERT, which may facilitate cellular differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0884-0431
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
897-906
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17352650-Adult, pubmed-meshheading:17352650-Alkaline Phosphatase, pubmed-meshheading:17352650-Antigens, Surface, pubmed-meshheading:17352650-Binding Sites, pubmed-meshheading:17352650-Cell Differentiation, pubmed-meshheading:17352650-Cell Proliferation, pubmed-meshheading:17352650-Cells, Cultured, pubmed-meshheading:17352650-Chromatin Immunoprecipitation, pubmed-meshheading:17352650-Core Binding Factor Alpha 1 Subunit, pubmed-meshheading:17352650-Culture Media, Serum-Free, pubmed-meshheading:17352650-Electrophoretic Mobility Shift Assay, pubmed-meshheading:17352650-Gene Expression Regulation, pubmed-meshheading:17352650-Humans, pubmed-meshheading:17352650-Mesenchymal Stem Cells, pubmed-meshheading:17352650-Mutation, pubmed-meshheading:17352650-Oligodeoxyribonucleotides, pubmed-meshheading:17352650-Osteoblasts, pubmed-meshheading:17352650-Platelet-Derived Growth Factor, pubmed-meshheading:17352650-Promoter Regions, Genetic, pubmed-meshheading:17352650-Protein Binding, pubmed-meshheading:17352650-Telomerase, pubmed-meshheading:17352650-Transfection, pubmed-meshheading:17352650-Transforming Growth Factor beta1
pubmed:year
2007
pubmed:articleTitle
hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations.
pubmed:affiliation
Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science/University of Adelaide, South Australia, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't