Linked Life Data

17351970

Source:http://linkedlifedata.com/resource/pubmed/id/17351970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-3-19
pubmed:abstractText
Fibrosis occurs in most chronic liver injuries and results from changes in the balance between synthesis and degradation of extracellular matrix (ECM) components. Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) are known to regulate the ECM turnover. We investigate the effect of modified synthetic small interfering RNA (siRNA) targeting TIMP-2 in rat model of liver fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase, http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I, http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type III, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 14, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of..., http://linkedlifedata.com/resource/pubmed/chemical/smooth muscle actin, rat
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1099-498X
pubmed:author
pubmed:copyrightInfo
Copyright 2007 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-29
pubmed:meshHeading
pubmed-meshheading:17351970-Actins, pubmed-meshheading:17351970-Alanine Transaminase, pubmed-meshheading:17351970-Animals, pubmed-meshheading:17351970-Aspartate Aminotransferases, pubmed-meshheading:17351970-Biological Markers, pubmed-meshheading:17351970-Cell Proliferation, pubmed-meshheading:17351970-Cells, Cultured, pubmed-meshheading:17351970-Collagen Type I, pubmed-meshheading:17351970-Collagen Type III, pubmed-meshheading:17351970-Extracellular Matrix, pubmed-meshheading:17351970-Gene Therapy, pubmed-meshheading:17351970-Hydroxyproline, pubmed-meshheading:17351970-Liver, pubmed-meshheading:17351970-Liver Cirrhosis, Experimental, pubmed-meshheading:17351970-Male, pubmed-meshheading:17351970-Matrix Metalloproteinase 13, pubmed-meshheading:17351970-Matrix Metalloproteinase 14, pubmed-meshheading:17351970-Matrix Metalloproteinase 2, pubmed-meshheading:17351970-RNA, Messenger, pubmed-meshheading:17351970-RNA, Small Interfering, pubmed-meshheading:17351970-Rats, pubmed-meshheading:17351970-Rats, Sprague-Dawley, pubmed-meshheading:17351970-Tissue Inhibitor of Metalloproteinase-2
pubmed:year
2007
pubmed:articleTitle
Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats.
pubmed:affiliation
Department of Digestive Diseases, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, P. R. China. huyingbin@gmail.com
pubmed:publicationType
Journal Article