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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-4-30
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pubmed:abstractText |
Recently, orthostatic hypotension was observed in patients with benign prostatic hyperplasia who are taking vardenafil (a PDE 5 inhibitor) and terazosin (a long acting alpha blocker). Therefore, this study was performed with DA-8159 (a long acting PDE 5 inhibitor) and terazosin in rats to find whether or not pharmacokinetic and pharmacodynamic interactions between the two drugs were observed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-10644054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-11043762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-11512128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-1164821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-12367677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-12774696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-12884246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-14603504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-15563761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-15801542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-15803515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-15926192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-15979430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-16765179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-480168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-499317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-6510253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-6678312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-731416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-7354453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-7791628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-8378254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-8410679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-8517864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-925882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17351661-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp3a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyp3a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/DA-8164,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Terazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Troleandomycin,
http://linkedlifedata.com/resource/pubmed/chemical/udenafil
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17351661-Animals,
pubmed-meshheading:17351661-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:17351661-Cytochrome P-450 CYP3A,
pubmed-meshheading:17351661-Dexamethasone,
pubmed-meshheading:17351661-Drug Interactions,
pubmed-meshheading:17351661-Male,
pubmed-meshheading:17351661-Membrane Proteins,
pubmed-meshheading:17351661-Microsomes, Liver,
pubmed-meshheading:17351661-Prazosin,
pubmed-meshheading:17351661-Pyrimidines,
pubmed-meshheading:17351661-Rats,
pubmed-meshheading:17351661-Rats, Sprague-Dawley,
pubmed-meshheading:17351661-Sulfonamides,
pubmed-meshheading:17351661-Troleandomycin
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pubmed:year |
2007
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pubmed:articleTitle |
Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats.
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pubmed:affiliation |
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak-Gu, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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