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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-3-12
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pubmed:abstractText |
The radioprotective effect of a hydroalcoholic extracted material (REC-2000) from the rhizome of Podophyllum hexandrum was studied in mice exposed to lethal gamma radiation (10 Gy). The extract (REC-2000) was found to restore the hemoglobin content (14.73 +/- 0.33) and total leukocyte count (TLC) (4166.66 +/- 0.02) in lethally (10 Gy) gamma-irradiated mice on the 15th day in comparison to the radiation control mice. The hemoglobin content of the drug + radiation group was observed to be significantly (21.25%) higher than the radiation control group on the 10th day. Similarly, the TLC was significantly increased (83.33 times) in the drug + radiation group as compared to a radiation (10 Gy) only group on the 10th day. Enhanced expression of heme-oxygenase-1 and Bcl-2 protein observed by Western blotting further supports the observation of hemopoietic recovery in irradiated mice. These findings indicate that the bioactive constituents present in REC-2000 exert the radioprotective effect by modulating the hemopoietic system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1534-7354
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pubmed:author |
pubmed-author:AroraRajeshR,
pubmed-author:GuptaMM,
pubmed-author:KrishnaBB,
pubmed-author:KumarRR,
pubmed-author:LahiriS SSS,
pubmed-author:PrasadJJ,
pubmed-author:REEDW AWA,
pubmed-author:SagarRR,
pubmed-author:SenoYY,
pubmed-author:SharmaA KAK,
pubmed-author:SharmaR KRK,
pubmed-author:SiddiquiM SMS,
pubmed-author:SinghSS,
pubmed-author:TripathiR PRP
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-65
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pubmed:meshHeading |
pubmed-meshheading:17351027-Animals,
pubmed-meshheading:17351027-Chromatography, High Pressure Liquid,
pubmed-meshheading:17351027-Gamma Rays,
pubmed-meshheading:17351027-Hematopoietic System,
pubmed-meshheading:17351027-Heme Oxygenase-1,
pubmed-meshheading:17351027-Hemoglobins,
pubmed-meshheading:17351027-Leukocytes,
pubmed-meshheading:17351027-Male,
pubmed-meshheading:17351027-Mice,
pubmed-meshheading:17351027-Mice, Inbred Strains,
pubmed-meshheading:17351027-Plant Extracts,
pubmed-meshheading:17351027-Podophyllum,
pubmed-meshheading:17351027-Proto-Oncogene Proteins,
pubmed-meshheading:17351027-Radiation Injuries, Experimental,
pubmed-meshheading:17351027-Radiation-Protective Agents,
pubmed-meshheading:17351027-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Cytoprotective effect of Podophyllum hexandrum against gamma radiation is mediated via hemopoietic system stimulation and up-regulation of heme-oxygenase-1 and the prosurvival multidomain protein Bcl-2.
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pubmed:affiliation |
Medicinal and Aromatic Plants Laboratory, Division of Radiation Biology and Radioprotection, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi-110 054, India. rajesharoradr@rediffmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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