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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
2007-4-2
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pubmed:abstractText |
Antimicrobial peptides have been recognized as a novel class of antibiotics, and several candidates are currently in clinical trials. In this work, a tripeptide derivative containing 4-iodo phenylalanine has been derivatized through the Suzuki-Miyaura cross-coupling. This has enabled the rapid and efficient synthesis of an array of tripeptide derivatives encompassing novel biaryl moieties. The peptide derivatives show high activity against Gram-positive bacteria.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
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|
pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2361-4
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pubmed:meshHeading |
pubmed-meshheading:17350833-Animals,
pubmed-meshheading:17350833-Anti-Bacterial Agents,
pubmed-meshheading:17350833-Calcium Signaling,
pubmed-meshheading:17350833-DNA-Binding Proteins,
pubmed-meshheading:17350833-Humans,
pubmed-meshheading:17350833-Inhibitory Concentration 50,
pubmed-meshheading:17350833-Mice,
pubmed-meshheading:17350833-Patch-Clamp Techniques,
pubmed-meshheading:17350833-Pharmacokinetics,
pubmed-meshheading:17350833-Protein Binding,
pubmed-meshheading:17350833-Receptors, Somatostatin,
pubmed-meshheading:17350833-Trans-Activators
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials.
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pubmed:affiliation |
Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway. bengt-erik.haug@farm.uib.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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