| pubmed-article:17350033 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C0027061 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:17350033 | lifeskim:mentions | umls-concept:C1955901 | lld:lifeskim |
| pubmed-article:17350033 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17350033 | pubmed:dateCreated | 2007-4-9 | lld:pubmed |
| pubmed-article:17350033 | pubmed:abstractText | We aimed to optimize non-viral transfection of human stromal cell derived factor (SDF-1alpha) gene into skeletal myoblasts (SkM) and, transplant these cells to establish transient SDF-1alpha gradient to favor extra-cardiac stem cell translocation into infarcted heart. Optimized conditions for transfection of SDF-1alpha gene into syngenic SkM were achieved using FuGene6/phSDF-1alpha (3:2v/w, 4 h transfection) with 125 microM ZnCl(2) (p<0.001). After characterization for transgene overexpression by immunostaining, ELISA and PCR, the cells were transplanted in female rat model of myocardial infarction. Thirty-six rats were grouped (n=12/group) to receive 70 microl DMEM without cells (group-1) or containing 1.5 x 10(6) non-transfected (group-2) or SDF-1alpha transfected SkM (group-3). On day 4 post-transplantation (in 4 animals/group), marked expression of SDF-1alpha/sry-gene (p=0.003), total Akt, phospho-Akt and Bcl2 was observed in group-3. The number of CD31(+), C-kit(+) and CD34(+) cells was highest in group-3 hearts (p<0.01). Blood vessel density in group-3 was higher in both scar and peri-scar regions (p<0.001) as compared with other groups. Echocardiography showed improved indices of left ventricle contractile function and remodeling in group-3 (p<0.05) as compared with groups-1 and -2. We conclude that ex vivo SDF-1alpha transgene delivery promotes stem and progenitor cell migration to the heart, activates cell survival signaling and enhances angiomyogenesis in the infarcted heart. | lld:pubmed |
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| pubmed-article:17350033 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17350033 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17350033 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17350033 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17350033 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:17350033 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:AshrafMuhamma... | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:LuGangG | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:HaiderHusnain... | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:JiangShujiaS | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:ElmadbouhII | lld:pubmed |
| pubmed-article:17350033 | pubmed:author | pubmed-author:IdrisNiagara... | lld:pubmed |
| pubmed-article:17350033 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17350033 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:17350033 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17350033 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17350033 | pubmed:pagination | 792-803 | lld:pubmed |
| pubmed-article:17350033 | pubmed:dateRevised | 2011-4-25 | lld:pubmed |
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| pubmed-article:17350033 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17350033 | pubmed:articleTitle | Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. | lld:pubmed |
| pubmed-article:17350033 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, 231-Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267-0529, USA. | lld:pubmed |
| pubmed-article:17350033 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17350033 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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