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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-3-20
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pubmed:abstractText |
Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. Brain-derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of autism. In this study, we examined the SNP- and haplotypic-association of BDNF with autism in a trios-based association study (the Autism Genetic Resource Exchange). We also examined the expression of BDNF mRNA in the peripheral blood lymphocytes of drug-naïve autism patients and control subjects. In the TDT of autism trios, the SNP haplotype combinations showed significant associations in the autism group. BDNF expression in the drug-naïve autistic group was found to be significantly higher than in the control group. We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:AnithaAA,
pubmed-author:HattoriEijiE,
pubmed-author:IwataYasuhideY,
pubmed-author:IwayamaYoshimiY,
pubmed-author:KawaiMasayoshiM,
pubmed-author:MatsuzakiHideoH,
pubmed-author:MiyachiTaishiT,
pubmed-author:MoriNorioN,
pubmed-author:NakamuraKazuhikoK,
pubmed-author:NishimuraKatsuhikoK,
pubmed-author:OuchiYasuomiY,
pubmed-author:SekineYoshimotoY,
pubmed-author:SudaShiroS,
pubmed-author:SugiharaGen-ichiG,
pubmed-author:SugiyamaToshiroT,
pubmed-author:SuzukiKatsuakiK,
pubmed-author:TakeiNoriN,
pubmed-author:ToyotaTomokoT,
pubmed-author:TsuchiyaKenjiK,
pubmed-author:TsujiiMasatsuguM,
pubmed-author:YamadaKazuoK,
pubmed-author:YoshikawaTakeoT
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
356
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
200-6
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pubmed:meshHeading |
pubmed-meshheading:17349978-Adult,
pubmed-meshheading:17349978-Autistic Disorder,
pubmed-meshheading:17349978-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:17349978-Child,
pubmed-meshheading:17349978-Female,
pubmed-meshheading:17349978-Gene Expression,
pubmed-meshheading:17349978-Gene Frequency,
pubmed-meshheading:17349978-Genotype,
pubmed-meshheading:17349978-Haplotypes,
pubmed-meshheading:17349978-Humans,
pubmed-meshheading:17349978-Linkage Disequilibrium,
pubmed-meshheading:17349978-Lymphocytes,
pubmed-meshheading:17349978-Male,
pubmed-meshheading:17349978-Nuclear Family,
pubmed-meshheading:17349978-Polymorphism, Single Nucleotide,
pubmed-meshheading:17349978-RNA, Messenger,
pubmed-meshheading:17349978-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2007
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pubmed:articleTitle |
Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism.
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pubmed:affiliation |
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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