Source:http://linkedlifedata.com/resource/pubmed/id/17348864
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-3-12
|
| pubmed:abstractText |
Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) function to remodel the pericellular environment. Their activation and regulation are associated with synaptic physiology and pathology. Here, we investigated whether MMP-2 and MMP-9 are involved in the rewarding effects of and sensitization to methamphetamine (METH) in animals, in which the remodelling of neural circuits may play a crucial role. Repeated METH treatment induced behavioural sensitization, which was accompanied by an increase in MMP-2 and MMP-9 activity in the brain. In MMP-2- and MMP-9-deficient mice [MMP-2-(-/-) and MMP-9-(-/-)], METH-induced behavioural sensitization and conditioned place preference, a measure of the rewarding effect, as well as METH-increased dopamine release in the nucleus accumbens (NAc) were attenuated compared with those in wild-type mice. In contrast, infusion of purified human MMP-2 into the NAc significantly potentiated the METH-increased dopamine release. The [(3)H]dopamine uptake into striatal synaptosomes was reduced in wild-type mice after repeated METH treatment, but METH-induced changes in [(3)H]dopamine uptake were significantly attenuated in MMP-2-(-/-) and MMP-9-(-/-) mice. These results suggest that both MMP-2 and MMP-9 play a crucial role in METH-induced behavioural sensitization and reward by regulating METH-induced dopamine release and uptake in the NAc.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Methamphetamine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0022-3042
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| pubmed:author |
pubmed-author:BannoYoshikoY,
pubmed-author:ItoharaShigeyoshiS,
pubmed-author:MizoguchiHiroyukiH,
pubmed-author:MizunoTomokoT,
pubmed-author:MouriAkihiroA,
pubmed-author:NabeshimaToshitakaT,
pubmed-author:NittaAtsumiA,
pubmed-author:NiwaMinaeM,
pubmed-author:NodaYukihiroY,
pubmed-author:YamadaKiyofumiK
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| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1579-88
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| pubmed:meshHeading |
pubmed-meshheading:17348864-Animals,
pubmed-meshheading:17348864-Behavior, Animal,
pubmed-meshheading:17348864-Central Nervous System Stimulants,
pubmed-meshheading:17348864-Conditioning, Operant,
pubmed-meshheading:17348864-Dopamine,
pubmed-meshheading:17348864-Drug Interactions,
pubmed-meshheading:17348864-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:17348864-Gene Expression,
pubmed-meshheading:17348864-Matrix Metalloproteinase 2,
pubmed-meshheading:17348864-Matrix Metalloproteinase 9,
pubmed-meshheading:17348864-Methamphetamine,
pubmed-meshheading:17348864-Mice,
pubmed-meshheading:17348864-Mice, Knockout,
pubmed-meshheading:17348864-Microdialysis,
pubmed-meshheading:17348864-Motor Activity,
pubmed-meshheading:17348864-Nucleus Accumbens,
pubmed-meshheading:17348864-Reward,
pubmed-meshheading:17348864-Time Factors
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| pubmed:year |
2007
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| pubmed:articleTitle |
Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice.
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| pubmed:affiliation |
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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