Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-12
pubmed:abstractText
Human embryonic stem (hES) cells hold great therapeutic potential for cell transplantation. To date, it remains uncertain whether undifferentiated hES cells can differentiate into cardiac lineage in vivo during myocardial infarction. Here we provide the first report that undifferentiated hES cells can survive in rat hearts during myocardial infarction without the formation of teratoma using undifferentiated green fluorescent protein (GFP)-transgenic hES cells. Using a laser-capture microscope to dissect the GFP-positive cell area from the hES-injected hearts, we documented the expression of human cardiac-specific genes, including GATA-4, Nkx-2.5, and cardiac troponin I. Taken together, our results demonstrate that undifferentiated hES cells can be driven to the cardiac lineage under the local injured environment in the heart, which may provide a potential method for regenerating de novo myocardium to treat myocardial infarction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1547-3287
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-9
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17348803-Animals, pubmed-meshheading:17348803-Cell Differentiation, pubmed-meshheading:17348803-Disease Models, Animal, pubmed-meshheading:17348803-Embryonic Stem Cells, pubmed-meshheading:17348803-GATA4 Transcription Factor, pubmed-meshheading:17348803-Green Fluorescent Proteins, pubmed-meshheading:17348803-Homeodomain Proteins, pubmed-meshheading:17348803-Humans, pubmed-meshheading:17348803-Microscopy, Confocal, pubmed-meshheading:17348803-Myocardial Infarction, pubmed-meshheading:17348803-Myocardium, pubmed-meshheading:17348803-Myocytes, Cardiac, pubmed-meshheading:17348803-Rats, pubmed-meshheading:17348803-Stem Cell Transplantation, pubmed-meshheading:17348803-Transcription Factors, pubmed-meshheading:17348803-Transgenes, pubmed-meshheading:17348803-Transplantation, Heterologous, pubmed-meshheading:17348803-Troponin I
pubmed:year
2007
pubmed:articleTitle
Transplantation of human undifferentiated embryonic stem cells into a myocardial infarction rat model.
pubmed:affiliation
Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural