Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-3-4
pubmed:abstractText
We have constructed a high-resolution genetic linkage map in the vicinity of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation causing this disease, inherited as an autosomal dominant, predisposes carriers to development of neoplastic tumors in the parathyroid, the endocrine pancreas, and the anterior lobe of the pituitary. The 12 markers on the genetic linkage map reported here span nearly 20 cM, and linkage analysis of MEN1 pedigrees has placed the MEN1 locus within the 8-cM region between D11S480 and D11S546. The markers on this map will be useful for prenatal or presymptomatic diagnosis of individuals in families that segregate a mutant allele of the MEN1 gene.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-1346079, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-1670689, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-1671318, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-1671755, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-1968641, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2461546, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2565085, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2883195, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2894610, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2900809, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-2903664, http://linkedlifedata.com/resource/pubmed/commentcorrection/1734719-6587361
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:geneSymbol
MEN1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-403
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).
pubmed:affiliation
Department of Biochemistry, Cancer Institute, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't