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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-5-7
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pubmed:abstractText |
Mutations in cardiac ryanodine receptors (RyR2s) are linked to catecholaminergic polymorphic ventricular tachycardia (CPVT), characterized by risk of polymorphic ventricular tachyarrhythmias and sudden death during exercise. Arrhythmias are caused by gain-of-function defects in RyR2, but cellular arrhythmogenesis remains elusive.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0195-668X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1135-42
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pubmed:meshHeading |
pubmed-meshheading:17347175-Action Potentials,
pubmed-meshheading:17347175-Adrenergic Agonists,
pubmed-meshheading:17347175-Adult,
pubmed-meshheading:17347175-Caffeine,
pubmed-meshheading:17347175-Calcium,
pubmed-meshheading:17347175-Central Nervous System Stimulants,
pubmed-meshheading:17347175-Cyclic AMP,
pubmed-meshheading:17347175-Epinephrine,
pubmed-meshheading:17347175-Female,
pubmed-meshheading:17347175-Heart Conduction System,
pubmed-meshheading:17347175-Humans,
pubmed-meshheading:17347175-Male,
pubmed-meshheading:17347175-Mutation,
pubmed-meshheading:17347175-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:17347175-Tachycardia, Ventricular
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pubmed:year |
2007
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pubmed:articleTitle |
Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves.
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pubmed:affiliation |
Minerva Foundation Institute for Medical Research, FIN-00290, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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