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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-4-6
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pubmed:abstractText |
The fungus Daedalea quercina (oak mazegill) was examined for its capability of producing antioxidative and anti-inflammatory compounds. Bioactivity guided fractionation of the extract from a mycelial culture led to the isolation of quercinol, which was identified as (-)-(2S)-2-hydroxymethyl-2-methyl-6-hydroxychromene 1 by NMR and X-ray analyses. The cryptic hydroquinone 1 shows a broad anti-inflammatory activity against cyclooxygenase 2 (COX-2), xanthine oxidase (XO), and horseradish peroxidase (HRP) at micromolar concentrations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2558-60
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17346963-Anti-Inflammatory Agents,
pubmed-meshheading:17346963-Basidiomycota,
pubmed-meshheading:17346963-Benzopyrans,
pubmed-meshheading:17346963-Chemistry, Pharmaceutical,
pubmed-meshheading:17346963-Crystallography, X-Ray,
pubmed-meshheading:17346963-Cyclooxygenase 2,
pubmed-meshheading:17346963-Cyclooxygenase Inhibitors,
pubmed-meshheading:17346963-Drug Design,
pubmed-meshheading:17346963-Horseradish Peroxidase,
pubmed-meshheading:17346963-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17346963-Models, Chemical,
pubmed-meshheading:17346963-Molecular Conformation,
pubmed-meshheading:17346963-Xanthine Oxidase
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pubmed:year |
2007
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pubmed:articleTitle |
Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
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pubmed:affiliation |
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, 07745 Jena, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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