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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-3-7
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pubmed:abstractText |
Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1021-335X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
713-9
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pubmed:meshHeading |
pubmed-meshheading:17342305-Animals,
pubmed-meshheading:17342305-BRCA1 Protein,
pubmed-meshheading:17342305-Dietary Fats, Unsaturated,
pubmed-meshheading:17342305-Docosahexaenoic Acids,
pubmed-meshheading:17342305-Fatty Acids, Omega-3,
pubmed-meshheading:17342305-Female,
pubmed-meshheading:17342305-Mammary Neoplasms, Animal,
pubmed-meshheading:17342305-RNA, Messenger,
pubmed-meshheading:17342305-Rats,
pubmed-meshheading:17342305-Rats, Sprague-Dawley,
pubmed-meshheading:17342305-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.
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pubmed:affiliation |
INSERM, E 0211; Université François Rabelais; CHU Bretonneau, Tours, F-37000, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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