Linked Life Data

17342030

Source:http://linkedlifedata.com/resource/pubmed/id/17342030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-3-7
pubmed:abstractText
Diabetes mellitus is a chronic disease characterized by hyperglycaemia and carbohydrate, fat and protein metabolism abnormalities, all due to an impairment in insulin homeostasis and a diffuse microangiopathy most involving retina, kidney and nerves. Several mechanisms are altered at a molecular level and interplay to develop the slow but devastating clinical impairments related to microangiopathy. Polyol pathway, advanced glycation endproducts, protein kinase C, hexosamine pathway and oxidative stress are among those mechanisms. Molecular pathways of diabetes from hyperglycaemia to signalling cascades alterations and the most promising strategies for successful therapeutic approaches derived from better knowledge of biochemical mechanisms are treated extensively in the present review.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1565-4753
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-52
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:articleTitle
The molecular basis of diabetic microangiopathy.
pubmed:affiliation
Department of Pediatrics, University of Chieti, Italy.
pubmed:publicationType
Journal Article, Review