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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-26
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pubmed:abstractText |
Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7alpha-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-5
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pubmed:meshHeading |
pubmed-meshheading:17341815-Amino Acids,
pubmed-meshheading:17341815-Cell Line,
pubmed-meshheading:17341815-Cell Line, Tumor,
pubmed-meshheading:17341815-Cholesterol 7-alpha-Hydroxylase,
pubmed-meshheading:17341815-Dipeptides,
pubmed-meshheading:17341815-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17341815-Humans,
pubmed-meshheading:17341815-Lysine,
pubmed-meshheading:17341815-RNA, Messenger
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells.
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pubmed:affiliation |
Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan.
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pubmed:publicationType |
Journal Article
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