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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-4-17
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pubmed:abstractText |
Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2582-9
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:17340616-Aged,
pubmed-meshheading:17340616-Aged, 80 and over,
pubmed-meshheading:17340616-Annexin A1,
pubmed-meshheading:17340616-Cell Line, Tumor,
pubmed-meshheading:17340616-Epithelial Cells,
pubmed-meshheading:17340616-Gene Expression,
pubmed-meshheading:17340616-Gene Expression Profiling,
pubmed-meshheading:17340616-Humans,
pubmed-meshheading:17340616-Immunohistochemistry,
pubmed-meshheading:17340616-Laryngeal Neoplasms,
pubmed-meshheading:17340616-Larynx,
pubmed-meshheading:17340616-Male,
pubmed-meshheading:17340616-Mast Cells,
pubmed-meshheading:17340616-Microscopy, Immunoelectron,
pubmed-meshheading:17340616-Middle Aged,
pubmed-meshheading:17340616-Peptides,
pubmed-meshheading:17340616-RNA, Messenger,
pubmed-meshheading:17340616-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17340616-Time Factors,
pubmed-meshheading:17340616-Tryptases
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pubmed:year |
2007
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pubmed:articleTitle |
Annexin 1: differential expression in tumor and mast cells in human larynx cancer.
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pubmed:affiliation |
Department of Biology, Instituto de Biociências, Letras e Ciências Exatas (IBILCE), São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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