The importance of B-type natriuretic peptide (BNP) as a diagnostic and therapeutic modality in cardiovascular disease is well known. BNP levels correlate clinical and physiologic characteristics, as well as outcomes. We sought to investigate the influence of BNP pathway genetic variation on BNP levels after adjustment for clinical/physiologic factors.
Section of Advanced Heart Failure and Cardiac Transplantation, Henry Ford Heart and Vascular Institute, Henry Ford Hospital, 2799 W. Grand Boulevard, Cardiology K14, Detroit, MI 48202, USA. dlanfea1@hfhs.org