| pubmed-article:17339638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C0023980 | lld:lifeskim |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C1456706 | lld:lifeskim |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C0011289 | lld:lifeskim |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C0220812 | lld:lifeskim |
| pubmed-article:17339638 | lifeskim:mentions | umls-concept:C0231449 | lld:lifeskim |
| pubmed-article:17339638 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17339638 | pubmed:dateCreated | 2007-3-6 | lld:pubmed |
| pubmed-article:17339638 | pubmed:abstractText | We monitored survival and reproduction of 1000 individuals of Caenorhabditis elegans wild type (N2) and 800 individuals of clk-1 and daf-2, and used biodemographic analysis to address fitness as the integrative consequence of the entire age-specific schedules of survival and reproduction. Relative to N2, the mutants clk-1 and daf-2 extended average life span by 27% and 111%, respectively, but reduced net reproductive rate by 44% and 18%. The net result of differences in survival and fertility was a significant differential in fitness, with both clk-1 (lambda = 2.74) and daf-2 (lambda = 3.78) at a disadvantage relative to N2 (lambda = 3.85). Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6-7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence. | lld:pubmed |
| pubmed-article:17339638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17339638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17339638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17339638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17339638 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17339638 | pubmed:issn | 1079-5006 | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:MüllerHans-Ge... | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:CaswellHalH | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:ChenJianjunJ | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:CareyJames... | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:WangJane-Ling... | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:Caswell-ChenE... | lld:pubmed |
| pubmed-article:17339638 | pubmed:author | pubmed-author:SenturkDamlaD | lld:pubmed |
| pubmed-article:17339638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17339638 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:17339638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17339638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17339638 | pubmed:pagination | 126-35 | lld:pubmed |
| pubmed-article:17339638 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:meshHeading | pubmed-meshheading:17339638... | lld:pubmed |
| pubmed-article:17339638 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17339638 | pubmed:articleTitle | A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:17339638 | pubmed:affiliation | Department of Nematology, University of California, Davis, CA 95616, USA. | lld:pubmed |
| pubmed-article:17339638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17339638 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:17339638 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17339638 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17339638 | lld:pubmed |
