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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-3-6
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pubmed:abstractText |
We monitored survival and reproduction of 1000 individuals of Caenorhabditis elegans wild type (N2) and 800 individuals of clk-1 and daf-2, and used biodemographic analysis to address fitness as the integrative consequence of the entire age-specific schedules of survival and reproduction. Relative to N2, the mutants clk-1 and daf-2 extended average life span by 27% and 111%, respectively, but reduced net reproductive rate by 44% and 18%. The net result of differences in survival and fertility was a significant differential in fitness, with both clk-1 (lambda = 2.74) and daf-2 (lambda = 3.78) at a disadvantage relative to N2 (lambda = 3.85). Demographic life table response experiment (LTRE) analysis revealed that the fitness differentials were due to negative effects in mutants on reproduction in the first 6-7 days of life. Fitness costs in clk-1 and daf-2 of C. elegans are consistent with the theory of antagonistic pleiotropy for the evolution of senescence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10202142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10360574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10500188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10617200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10638522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-10830948,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-11250116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-12397350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-12878733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-1411541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-15153180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-15268752,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-16373574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-16963216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-17148178,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-4366476,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-7973642,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17339638-9725835
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1079-5006
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
126-35
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17339638-Aging,
pubmed-meshheading:17339638-Animals,
pubmed-meshheading:17339638-Caenorhabditis elegans,
pubmed-meshheading:17339638-Caenorhabditis elegans Proteins,
pubmed-meshheading:17339638-Longevity,
pubmed-meshheading:17339638-Mathematical Computing,
pubmed-meshheading:17339638-Models, Animal,
pubmed-meshheading:17339638-Mutation,
pubmed-meshheading:17339638-Receptor, Insulin,
pubmed-meshheading:17339638-Reproduction,
pubmed-meshheading:17339638-Survival Analysis
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pubmed:year |
2007
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pubmed:articleTitle |
A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans.
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pubmed:affiliation |
Department of Nematology, University of California, Davis, CA 95616, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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