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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-3-6
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pubmed:abstractText |
Neonates suffer unduly from infections and also respond suboptimally to most commonly used vaccines. However, a CD8 T cell response can be elicited in neonates if the Ag is introduced into the cytoplasm of APCs. Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice. We hypothesized that an attenuated strain of Lm would be safe and induce long-lasting protective immunity, even in neonates. We found that neonatal mice immunized only once with the attenuated strain DeltaactA-Lm developed robust primary and secondary CD8 and CD4 Th1 responses and were fully protected from lethal challenge with virulent wild-type Lm without the need for a booster immunization. Furthermore, DeltaactA-Lm expressing a heterologous recombinant Ag induced a strong CD8 and Th1 memory response to that Ag. Based on these data, we propose that DeltaactA-Lm or derivatives thereof might serve as a vaccine vehicle for neonatal immunization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-10453021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-11119576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-11348697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-11752181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-11823519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-12244184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-12391214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-12615899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-12782677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-12847214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-14764107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-14978015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-14978134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15084272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15210801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15229474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15294984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15365184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15532991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-15958064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-16113339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-3081575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-3081678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-3997246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-7621071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-8265643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-8543821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-9120295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-9529152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17339467-9711791
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3695-701
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17339467-Animals,
pubmed-meshheading:17339467-Animals, Newborn,
pubmed-meshheading:17339467-Antigen-Presenting Cells,
pubmed-meshheading:17339467-Antigens, Bacterial,
pubmed-meshheading:17339467-Bacterial Proteins,
pubmed-meshheading:17339467-Bacterial Vaccines,
pubmed-meshheading:17339467-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17339467-Listeria monocytogenes,
pubmed-meshheading:17339467-Listeriosis,
pubmed-meshheading:17339467-Membrane Proteins,
pubmed-meshheading:17339467-Mice,
pubmed-meshheading:17339467-Th1 Cells,
pubmed-meshheading:17339467-Vaccines, Attenuated
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pubmed:year |
2007
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pubmed:articleTitle |
Induction of protective immunity to Listeria monocytogenes in neonates.
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pubmed:affiliation |
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA. tkollmann@cw.bc.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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