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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-3-6
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pubmed:abstractText |
Deficient thymopoiesis and retarded recovery of newly developed CD4(+) T cells is one of the most important determinants of impaired immunocompetence after hemopoietic stem cell transplantation. Here we evaluated whether Fms-like tyrosine kinase 3 (Flt3) ligand (FL) alone or combined with IL-7 affects T cell recovery, thymopoiesis, and lymphoid progenitor expansion following bone marrow transplantation in immunodeficient mice. FL strongly accelerated and enhanced the recovery of peripheral T cells after transplantation of a low number of bone marrow cells. An additive effect on T cell recovery was not observed after coadministration of IL-7. Lineage(-)sca-1(+)c-kit(+)flt3(+) lymphoid progenitor cell numbers were significantly increased in bone marrow of FL-treated mice before recovery of thymopoiesis. Thymocyte differentiation was advanced to more mature stages after FL treatment. Improved T cell recovery resulted in better immunocompetence against a post-bone marrow transplantation murine CMV infection. Collectively, our data suggest that FL promotes T cell recovery by enhanced thymopoiesis and by expansion of lymphoid progenitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BraakmanEricE,
pubmed-author:BroersAnnoek E CAE,
pubmed-author:CornelissenJan JJJ,
pubmed-author:LöwenbergBobB,
pubmed-author:NiestersHubert G MHG,
pubmed-author:RomboutsElwin J CEJ,
pubmed-author:SpitsHergenH,
pubmed-author:StaalFrank J TFJ,
pubmed-author:VerjansGeorges M G MGM,
pubmed-author:WagemakerGerardG,
pubmed-author:WilsEvert-JanEJ
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3551-7
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pubmed:meshHeading |
pubmed-meshheading:17339451-Animals,
pubmed-meshheading:17339451-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:17339451-Bone Marrow Transplantation,
pubmed-meshheading:17339451-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17339451-Cell Differentiation,
pubmed-meshheading:17339451-Hematopoietic Stem Cells,
pubmed-meshheading:17339451-Humans,
pubmed-meshheading:17339451-Interleukin-7,
pubmed-meshheading:17339451-Lymphopoiesis,
pubmed-meshheading:17339451-Membrane Proteins,
pubmed-meshheading:17339451-Mice,
pubmed-meshheading:17339451-Mice, Inbred BALB C,
pubmed-meshheading:17339451-Mice, Knockout,
pubmed-meshheading:17339451-Recovery of Function,
pubmed-meshheading:17339451-Thymus Gland
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pubmed:year |
2007
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pubmed:articleTitle |
Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation.
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pubmed:affiliation |
Department of Hematology, Erasmus Medical Center/Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3071 EA Amsterdam, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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