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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-2-28
|
| pubmed:abstractText |
Cognitive function and mood of patients with epilepsy who received 2 g/day vigabatrin (GVG) in addition to their usual antiepileptic drugs (AEDs) was assessed on two occasions: before start of treatment (baseline) and 4 weeks after start of treatment. A battery of selected psychological tasks measuring attention, mental speed, motor speed, central cognitive processing, and perceptuomotor performance was used, along with standardized, objective mood assessments. A comparison group (n = 15) of patients receiving stable medication was also tested to evaluate practice effects of the psychometric tests. Administration of 2 g/day GVG significantly decreased response time on a test of central cognitive processing ability (arithmetic). No adverse effect was noted on any other test of cognitive function or mood.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0013-9580
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
128-34
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1733746-Adult,
pubmed-meshheading:1733746-Affect,
pubmed-meshheading:1733746-Aminocaproic Acids,
pubmed-meshheading:1733746-Anticonvulsants,
pubmed-meshheading:1733746-Cognition,
pubmed-meshheading:1733746-Decision Making,
pubmed-meshheading:1733746-Dose-Response Relationship, Drug,
pubmed-meshheading:1733746-Epilepsy,
pubmed-meshheading:1733746-Female,
pubmed-meshheading:1733746-Flicker Fusion,
pubmed-meshheading:1733746-Humans,
pubmed-meshheading:1733746-Male,
pubmed-meshheading:1733746-Middle Aged,
pubmed-meshheading:1733746-Personality Inventory,
pubmed-meshheading:1733746-Practice (Psychology),
pubmed-meshheading:1733746-Psychological Tests,
pubmed-meshheading:1733746-Psychomotor Performance,
pubmed-meshheading:1733746-Reaction Time,
pubmed-meshheading:1733746-Vigabatrin
|
| pubmed:articleTitle |
Effects of vigabatrin on cognitive function and mood when used as add-on therapy in patients with intractable epilepsy.
|
| pubmed:affiliation |
Institute of Neurology, National Hospital, London, England.
|
| pubmed:publicationType |
Journal Article
|