Linked Life Data

17337340

Source:http://linkedlifedata.com/resource/pubmed/id/17337340

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
2007-4-2
pubmed:abstractText
This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0924-977X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
492-500
pubmed:meshHeading
pubmed:articleTitle
Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study.
pubmed:affiliation
Division of Psychological Medicine Institute of Psychiatry, King's College London, De Crespigny Park, SE58AF, London, UK. p.fusar@libero.it
pubmed:publicationType
Journal Article