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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0017337,
umls-concept:C0030705,
umls-concept:C0035820,
umls-concept:C0070166,
umls-concept:C0178602,
umls-concept:C0702240,
umls-concept:C0871261,
umls-concept:C0948089,
umls-concept:C1425330,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1708715,
umls-concept:C1882417,
umls-concept:C2346689,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2007-9-24
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pubmed:abstractText |
Variability in platelet response to clopidogrel and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunteers, suggesting a possible mechanism for modulation of clopidogrel response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P2RY12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y12,
http://linkedlifedata.com/resource/pubmed/chemical/Ticlopidine,
http://linkedlifedata.com/resource/pubmed/chemical/clopidogrel,
http://linkedlifedata.com/resource/pubmed/chemical/vasodilator-stimulated...
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pubmed:status |
MEDLINE
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pubmed:issn |
0049-3848
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
893-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17337040-Acute Disease,
pubmed-meshheading:17337040-Aged,
pubmed-meshheading:17337040-Blood Platelets,
pubmed-meshheading:17337040-Cell Adhesion Molecules,
pubmed-meshheading:17337040-Drug Resistance,
pubmed-meshheading:17337040-Electrocardiography,
pubmed-meshheading:17337040-Female,
pubmed-meshheading:17337040-Gene Frequency,
pubmed-meshheading:17337040-Genotype,
pubmed-meshheading:17337040-Heart Diseases,
pubmed-meshheading:17337040-Heterozygote,
pubmed-meshheading:17337040-Homozygote,
pubmed-meshheading:17337040-Humans,
pubmed-meshheading:17337040-Male,
pubmed-meshheading:17337040-Microfilament Proteins,
pubmed-meshheading:17337040-Middle Aged,
pubmed-meshheading:17337040-P-Selectin,
pubmed-meshheading:17337040-Phosphoproteins,
pubmed-meshheading:17337040-Phosphorylation,
pubmed-meshheading:17337040-Platelet Aggregation,
pubmed-meshheading:17337040-Platelet Aggregation Inhibitors,
pubmed-meshheading:17337040-Polymorphism, Genetic,
pubmed-meshheading:17337040-Receptors, Purinergic P2,
pubmed-meshheading:17337040-Receptors, Purinergic P2Y12,
pubmed-meshheading:17337040-Ticlopidine
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pubmed:year |
2007
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pubmed:articleTitle |
Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome.
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pubmed:affiliation |
Department of Cardiology, CHU Timone, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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