Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-3-22
pubmed:abstractText
Frontal-subcortical abnormalities have been implicated in the pathophysiology of Tourette syndrome (TS). The goal of this study was to more extensively evaluate a possible underlying neurochemical abnormality in frontal cortex. Postmortem brain tissue from frontal and occipital regions (Brodmann's areas 4, 6, 9, 10, 11, 12, and 17) from three TS patients and three age-and sex-matched controls were analyzed by semiquantitative immunoblotting. Relative densities were measured for a variety of neurochemical markers including dopamine (D1, D2), serotonin (5HT-1A), and alpha-adrenergic (alpha-2A) receptors, the dopamine transporter (DAT), a monoamine terminal marker (vesicular monoamine transporter type 2, VMAT-2), and vesicular docking and release proteins (VAMP-2, synaptotagmin, SNAP-25, syntaxin, synaptophysin). Data from each TS sample, corrected for actin content, was expressed as a percentage value of its control. Results identified consistent increases of DAT and D2 receptor density in five of six frontal regions in all three TS subjects. D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
255
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
50-6
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17337006-Adult, pubmed-meshheading:17337006-Biological Markers, pubmed-meshheading:17337006-Brain Chemistry, pubmed-meshheading:17337006-Dopamine, pubmed-meshheading:17337006-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:17337006-Female, pubmed-meshheading:17337006-Humans, pubmed-meshheading:17337006-Male, pubmed-meshheading:17337006-Middle Aged, pubmed-meshheading:17337006-Nerve Tissue Proteins, pubmed-meshheading:17337006-Predictive Value of Tests, pubmed-meshheading:17337006-Prefrontal Cortex, pubmed-meshheading:17337006-Receptors, Dopamine D2, pubmed-meshheading:17337006-Reference Values, pubmed-meshheading:17337006-Synaptic Membranes, pubmed-meshheading:17337006-Synaptic Vesicles, pubmed-meshheading:17337006-Tourette Syndrome, pubmed-meshheading:17337006-Up-Regulation
pubmed:year
2007
pubmed:articleTitle
Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.
pubmed:affiliation
Department of Neurology, Johns Hopkins University School of Medicine, Harriett Lane Outpatient Building, 200 N. Wolfe Street, Suite 2158, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural