Linked Life Data

17336829

Source:http://linkedlifedata.com/resource/pubmed/id/17336829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-3-5
pubmed:abstractText
We studied an in vivo mouse model to evaluate the relationships between CD26--a glycoprotein with dipeptidyl peptidase IV (DPP-IV) activity implicated in the regulation of immune functions--and T cells expressing the effector/memory phenotype CD45RB. We report that CD26 does not define a differentiation stage of CD4 T cells because the density and frequency of CD26 on CD4 T cells from the spleen, inguinal and mesenteric lymph node was similar within the CD45RB+ (naïve) and CD45RB- (antigen primed) subsets. This observation was confirmed using CD4 T cells from a T-cell receptor transgenic (tg) model. CD4 tg T cells specific for ovalbumin (OVA) were adoptively transferred and challenged in vivo with antigen. CD26 expression was the same on naive and antigen-stimulated CD4 T cells. Depleting CD4 T cells with an anti-CD4 antibody preferentially depleted the CD45RB+ subset. In CD4 depleted animals CD26 expression was not altered on the CD45RB- subset but the density of CD26 was marginally increased on the remaining CD45RB+ CD4 T cells. The results suggest that, unlike the human, CD26 in the mouse was not directly linked with T cell activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-2985
pubmed:author
pubmed:issnType
Print
pubmed:volume
212
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-94
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
On the role of CD26 in CD4 memory T cells.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, Santiago de Compostela, Spain. bnojcord@usc.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't