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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-12
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pubmed:abstractText |
Some oxime ether-substituted aryloxypropanolamines 3-5, structurally related to the active metabolite 2 of sarpogrelate 1, were synthesized and tested for their affinities at 5-HT2A and 5-HT1A serotoninergic receptors as well as at the alpha1-adrenoceptor. The results show that the compounds possess, at least partially, the ability of the model compounds 1 and 2 to interact with the 5-HT2A-receptors; they have the same selectivity towards 5-HT2A receptors vs alpha1-adrenoceptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ketanserin,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Oximes,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Succinates,
http://linkedlifedata.com/resource/pubmed/chemical/sarpogrelate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0365-6233
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
340
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17335104-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:17335104-Adrenergic alpha-Antagonists,
pubmed-meshheading:17335104-Animals,
pubmed-meshheading:17335104-Binding, Competitive,
pubmed-meshheading:17335104-Cerebral Cortex,
pubmed-meshheading:17335104-Ketanserin,
pubmed-meshheading:17335104-Ligands,
pubmed-meshheading:17335104-Molecular Structure,
pubmed-meshheading:17335104-Oximes,
pubmed-meshheading:17335104-Piperazines,
pubmed-meshheading:17335104-Prazosin,
pubmed-meshheading:17335104-Protein Binding,
pubmed-meshheading:17335104-Pyridines,
pubmed-meshheading:17335104-Rats,
pubmed-meshheading:17335104-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:17335104-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:17335104-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:17335104-Serotonin Antagonists,
pubmed-meshheading:17335104-Serotonin Receptor Agonists,
pubmed-meshheading:17335104-Structure-Activity Relationship,
pubmed-meshheading:17335104-Succinates
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl oximes.
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pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Pisa, Italy. eorlandini@farm.unipi.it
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pubmed:publicationType |
Journal Article,
In Vitro
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