Source:http://linkedlifedata.com/resource/pubmed/id/17335080
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2007-5-24
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pubmed:abstractText |
The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play a positive role in nerve regeneration by forming neurotrophin chemoattractant gradients or by competitively antagonizing the NOGO/NgR/LINGO-1 signal through cell-cell contact or regulated intramembranous proteolysis (RIP) of p75NTR. This piece presents some recent evidence supporting this hypothesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0360-4012
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1601-5
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pubmed:meshHeading |
pubmed-meshheading:17335080-Animals,
pubmed-meshheading:17335080-Axons,
pubmed-meshheading:17335080-Humans,
pubmed-meshheading:17335080-Nerve Growth Factors,
pubmed-meshheading:17335080-Nerve Regeneration,
pubmed-meshheading:17335080-Neuroglia,
pubmed-meshheading:17335080-Receptor, Nerve Growth Factor,
pubmed-meshheading:17335080-Schwann Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Roles of glial p75NTR in axonal regeneration.
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pubmed:affiliation |
Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia. xin-fu.zhou@flinders.edu.au
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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