Linked Life Data

17334981

Source:http://linkedlifedata.com/resource/pubmed/id/17334981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-3-21
pubmed:abstractText
Survivin functions as an apoptosis inhibitor and a regulator of cell division in many tumours. The intracellular localization of survivin in tumours has been suggested as a prognostic marker. However, current reports are inconsistent and the underlying molecular mechanisms are not understood. The present study has examined the localization and prognostic value of nuclear and cytoplasmic survivin in the pre-therapeutic biopsies from 71 oral and oropharyngeal squamous carcinoma (OSCC) patients. Statistical analysis indicated that preferential nuclear versus cytoplasmic survivin correlated with favourable versus unfavourable disease outcome. Uni- and multi-variate analysis showed that in contrast to total survivin expression, the difference between nuclear and cytoplasmic survivin was a strong predictor for relapse-free survival (p=0.0003). As a potential underlying molecular mechanism, it is shown in OSCC cell lines that predominantly cytoplasmic survivin mediates protection against chemo- and radio-therapy-induced apoptosis. Importantly, the cytoplasmic localization of survivin is regulated by its nuclear export signal (NES), and export-deficient nuclear survivin is not cytoprotective. This study suggests that the difference between cytoplasmic and nuclear survivin is an indicator for survivin activity in tumour cells. Thus, this difference may serve as a predictive marker of outcome in OSCC patients undergoing multi-modality therapy. The pharmacogenetic interference with survivin's cytoplasmic localization is also to be pursued as a potential therapeutic strategy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3417
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
532-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17334981-Apoptosis, pubmed-meshheading:17334981-Carcinoma, Squamous Cell, pubmed-meshheading:17334981-Cell Line, Tumor, pubmed-meshheading:17334981-Cell Nucleus, pubmed-meshheading:17334981-Cysteine Proteinase Inhibitors, pubmed-meshheading:17334981-Cytoplasm, pubmed-meshheading:17334981-Head and Neck Neoplasms, pubmed-meshheading:17334981-Humans, pubmed-meshheading:17334981-Immunohistochemistry, pubmed-meshheading:17334981-Inhibitor of Apoptosis Proteins, pubmed-meshheading:17334981-Kaplan-Meier Estimate, pubmed-meshheading:17334981-Karyopherins, pubmed-meshheading:17334981-Microtubule-Associated Proteins, pubmed-meshheading:17334981-Mouth Neoplasms, pubmed-meshheading:17334981-Neoplasm Proteins, pubmed-meshheading:17334981-Nuclear Export Signals, pubmed-meshheading:17334981-Oropharyngeal Neoplasms, pubmed-meshheading:17334981-Prognosis, pubmed-meshheading:17334981-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:17334981-Tumor Markers, Biological
pubmed:year
2007
pubmed:articleTitle
Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker.
pubmed:affiliation
Department of Pathology, University Hospital of Frankfurt, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't