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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-9-27
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pubmed:abstractText |
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract associated with dysregulation of the immune response. It is caused by a combination of environmental and genetic factors. Patients with CD have a TH1-type inflammatory response characterized by nuclear factor kappa B (NFkappaB) activation. Mutations in the bacterial pattern recognition receptors NOD2/CARD15 and Toll-like receptor 4 (TLR4) genes, which lead to activation of NFkappaB under normal circumstances, have been associated with increased susceptibility for CD. NFkappaB plays a critical role in the immune response and is down-regulated by NFkappaB inhibitor alpha (NFKBIA). NFKBIA was found to be a susceptibility gene for German CD patients lacking NOD2/CARD15 mutations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0179-1958
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1021-5
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pubmed:dateRevised |
2008-5-13
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pubmed:meshHeading |
pubmed-meshheading:17333217-3' Untranslated Regions,
pubmed-meshheading:17333217-Cohort Studies,
pubmed-meshheading:17333217-Crohn Disease,
pubmed-meshheading:17333217-Genotype,
pubmed-meshheading:17333217-Histocompatibility Antigens Class II,
pubmed-meshheading:17333217-Humans,
pubmed-meshheading:17333217-Israel,
pubmed-meshheading:17333217-NF-kappa B,
pubmed-meshheading:17333217-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:17333217-Polymorphism, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
Lack of association of the 3'-UTR polymorphism in the NFKBIA gene with Crohn's disease in an Israeli cohort.
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pubmed:affiliation |
Molecular Genetics Lab, E Wolfson Medical Center, POB 5, Holon, Israel, 58100. leshinsky@wolfson.health.gov.il
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pubmed:publicationType |
Journal Article
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