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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-3-2
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pubmed:abstractText |
Chromosomal aneuploidy is a defining feature of carcinomas. For instance, in colon cancer, an additional copy of Chromosome 7 is not only observed in early pre-malignant polyps, but is faithfully maintained throughout progression to metastasis. These copy number changes show a positive correlation with average transcript levels of resident genes. An independent line of research has also established that specific chromosomes occupy a well conserved 3D position within the interphase nucleus.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-10077600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-10366586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-11181992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-11777341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-11930003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12297621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12361574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12410231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12414653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12915492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-12952935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-15239829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-15466185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-15839726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-16215742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-16336643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-16489013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-16823176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-17044061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-7559784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-8521381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-8703845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332847-8703849
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e199
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pubmed:meshHeading |
pubmed-meshheading:17332847-Adenocarcinoma,
pubmed-meshheading:17332847-Aneuploidy,
pubmed-meshheading:17332847-Animals,
pubmed-meshheading:17332847-Chromosomes, Human, Pair 18,
pubmed-meshheading:17332847-Chromosomes, Human, Pair 19,
pubmed-meshheading:17332847-Chromosomes, Human, Pair 7,
pubmed-meshheading:17332847-Colonic Neoplasms,
pubmed-meshheading:17332847-Gene Dosage,
pubmed-meshheading:17332847-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17332847-Humans,
pubmed-meshheading:17332847-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17332847-Interphase,
pubmed-meshheading:17332847-Intranuclear Space,
pubmed-meshheading:17332847-Mice,
pubmed-meshheading:17332847-Microscopy, Confocal,
pubmed-meshheading:17332847-Transcription, Genetic,
pubmed-meshheading:17332847-Trisomy,
pubmed-meshheading:17332847-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells.
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pubmed:affiliation |
Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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