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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-23
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pubmed:abstractText |
The tumor suppressor p53 is a key transcriptional factor regulating the induction of cellular senescence by oncogenic signals. The activity of p53 is regulated by recruitment into promyelocytic leukemia (PML)-nuclear bodies (NBs) as well as by stabilization through posttranslational modifications such as phosphorylation and acetylation. Here we found that MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal human and mouse fibroblasts but not p53-/- fibroblasts. Conversely, genotoxic stress-induced phosphorylation and stabilization of p53 but barely increased its transcriptional activity in Morc3-/- fibroblasts. MORC3 localized on PML-NBs in presence of PML and mediated recruitment of p53 and CREB-binding protein (CBP) into PML-NBs. In contrast, expression of ATPase activity-deficient mutant MORC3-E35A or siRNA repression of MORC3 impaired the localization of p53 and Sp100 but not CBP on PML-NBs. These results suggest that MORC3 regulates p53 activity and localization into PML-NBs. We identified a new molecular mechanism that regulates the activity of nuclear proteins by localization to a nuclear subdomain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10199405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10369865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10477764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10637609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10793132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10871756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-10910364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-11080164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-11106738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-11740489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-11780126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-11927593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-12068306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-12093737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-12101223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-12459495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-12810724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-14607086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-15510160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-15657390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-15734683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-16079837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-16079851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-7568133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-7834749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-8048955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-8242752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-8293467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-8293468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-8900170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-9054499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-9707442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17332504-9826705
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/MORC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Morc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sp100 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sp100 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1059-1524
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1701-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17332504-Animals,
pubmed-meshheading:17332504-Antigens, Nuclear,
pubmed-meshheading:17332504-Autoantigens,
pubmed-meshheading:17332504-Cell Aging,
pubmed-meshheading:17332504-Cell Line,
pubmed-meshheading:17332504-Cell Nucleus,
pubmed-meshheading:17332504-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:17332504-Doxorubicin,
pubmed-meshheading:17332504-Fibroblasts,
pubmed-meshheading:17332504-Genes, p53,
pubmed-meshheading:17332504-HeLa Cells,
pubmed-meshheading:17332504-Humans,
pubmed-meshheading:17332504-Mice,
pubmed-meshheading:17332504-Mice, Inbred C57BL,
pubmed-meshheading:17332504-Mice, Knockout,
pubmed-meshheading:17332504-Nuclear Proteins,
pubmed-meshheading:17332504-Recombinant Fusion Proteins,
pubmed-meshheading:17332504-Transfection,
pubmed-meshheading:17332504-Tumor Suppressor Protein p53
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pubmed:year |
2007
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pubmed:articleTitle |
Dynamic regulation of p53 subnuclear localization and senescence by MORC3.
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pubmed:affiliation |
Department of Molecular Genetics and Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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