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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-30
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pubmed:databankReference |
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pubmed:abstractText |
Hyperhomocysteinemia has been associated with a higher risk of cardiovascular disease (CVD) in epidemiological studies, but recent trials have failed to show a benefit of lowering homocysteine. To address this apparent paradox, we explored whether interaction between genetic and dietary factors related to homocysteine metabolism contributes to CVD risk.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9147
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
845-51
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pubmed:dateRevised |
2008-3-12
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pubmed:meshHeading |
pubmed-meshheading:17332146-Cardiovascular Diseases,
pubmed-meshheading:17332146-Data Interpretation, Statistical,
pubmed-meshheading:17332146-Dietary Supplements,
pubmed-meshheading:17332146-Double-Blind Method,
pubmed-meshheading:17332146-Female,
pubmed-meshheading:17332146-Folic Acid,
pubmed-meshheading:17332146-Genotype,
pubmed-meshheading:17332146-Homocysteine,
pubmed-meshheading:17332146-Humans,
pubmed-meshheading:17332146-Incidence,
pubmed-meshheading:17332146-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:17332146-Middle Aged,
pubmed-meshheading:17332146-Polymerase Chain Reaction,
pubmed-meshheading:17332146-Polymorphism, Genetic,
pubmed-meshheading:17332146-Prospective Studies,
pubmed-meshheading:17332146-Risk Factors,
pubmed-meshheading:17332146-Vitamin B Complex
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pubmed:year |
2007
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pubmed:articleTitle |
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women.
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pubmed:affiliation |
Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. rzee@rics.bwh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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