Source:http://linkedlifedata.com/resource/pubmed/id/17331973
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2007-6-1
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pubmed:abstractText |
Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the alpha subunit of its receptor (IL10RA) are associated with changes in, or value of, forced expiratory volume in one second (FEV1) in smoking-induced chronic obstructive pulmonary disease. In total, eleven SNPs of IL10 and IL10RA were studied in 586 White subjects, selected from continuous smokers followed for 5 yrs in the Lung Health Study, who showed the fastest (n=280) and slowest (n=306) decline in FEV1. These 11 SNPs were also studied in 1,072 participants exhibiting the lowest (n=538) and highest (n=534) baseline FEV1 at the beginning of the Lung Health Study. No association was found in the primary analyses. Although a subgroup analysis showed that the IL-10 3368A allele was associated with a fast decline in FEV1, the association did not pass correction for multiple comparisons. No gene-gene interaction of IL10 with IL10RA was found. There was no association of polymorphisms of the genes encoding interleukin-10 and the alpha subunit of its receptor with the rate of decline in, or value of, forced expiratory volume in one second in smoking-induced chronic obstructive pulmonary disease.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0903-1936
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1120-6
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17331973-Adult,
pubmed-meshheading:17331973-Alleles,
pubmed-meshheading:17331973-Female,
pubmed-meshheading:17331973-Forced Expiratory Volume,
pubmed-meshheading:17331973-Genotype,
pubmed-meshheading:17331973-Humans,
pubmed-meshheading:17331973-Interleukin-10,
pubmed-meshheading:17331973-Interleukin-10 Receptor alpha Subunit,
pubmed-meshheading:17331973-Lung,
pubmed-meshheading:17331973-Lung Diseases,
pubmed-meshheading:17331973-Male,
pubmed-meshheading:17331973-Middle Aged,
pubmed-meshheading:17331973-Polymorphism, Genetic,
pubmed-meshheading:17331973-Polymorphism, Single Nucleotide,
pubmed-meshheading:17331973-Pulmonary Disease, Chronic Obstructive
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pubmed:year |
2007
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pubmed:articleTitle |
Polymorphisms of interleukin-10 and its receptor and lung function in COPD.
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pubmed:affiliation |
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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