Source:http://linkedlifedata.com/resource/pubmed/id/17331717
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2007-4-6
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pubmed:abstractText |
A series of sugar derivatives (7-14) were synthesized from stachyose, a sugar compound of Stachys sieboldi Miq, and evaluated for antibacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus, and their structure-activity relationships were studied. The results showed that the compound OCT359 (allyl O-(2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl)-(1-->6)-O-(2,3,4-tri-O-acetyl-alpha-D-galactopyranosyl)-(1-->6)-O-2,3,4-tri-O-acetyl-beta-D-glucopyranoside) (12) exhibited in vitro antibacterial activity. The allyl group at C-1 and the acetoxy groups of the manninotrioside were requisite for the antibacterial activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2487-91
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pubmed:meshHeading |
pubmed-meshheading:17331717-Anti-Bacterial Agents,
pubmed-meshheading:17331717-Carbohydrate Conformation,
pubmed-meshheading:17331717-Carbohydrate Sequence,
pubmed-meshheading:17331717-Carbohydrates,
pubmed-meshheading:17331717-Chemistry, Pharmaceutical,
pubmed-meshheading:17331717-Drug Design,
pubmed-meshheading:17331717-Molecular Sequence Data,
pubmed-meshheading:17331717-Mycobacterium avium,
pubmed-meshheading:17331717-Mycobacterium tuberculosis,
pubmed-meshheading:17331717-Plant Extracts,
pubmed-meshheading:17331717-Stachys,
pubmed-meshheading:17331717-Staphylococcus aureus
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.
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pubmed:affiliation |
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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